Which sign indicates naloxone has reversed opioid-induced respiratory depression?

• A. Decreased blood pressure
• B. Improved respiratory rate and effort, and regained level of consciousness
• C. Persistent drowsiness
• D. No change in mental status

Answer: (B)

Naloxone works by blocking opioid receptors, quickly reversing respiratory depression and CNS suppression caused by opioid overdose. The best sign that reversal has occurred is improved breathing with a higher respiratory rate and effort, along with regained or noticeably improved level of consciousness. This shows the opioids’ effects on both breathing and brain function have been countered. Persistent drowsiness indicates ongoing CNS depression, no change in mental status suggests reversal hasn’t occurred yet, and decreased blood pressure can result from other factors and doesn’t specifically show reversal of opioid effects. After administration, continue close monitoring because the effects of naloxone can wear off and re-narcotization is possible.