Nitroglycerin primarily reduces myocardial oxygen demand by causing venodilation that lowers which parameter?

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Multiple Choice

Nitroglycerin primarily reduces myocardial oxygen demand by causing venodilation that lowers which parameter?

Explanation:
Nitroglycerin reduces myocardial oxygen demand mainly by venodilation, which lowers preload. By dilating veins, it decreases venous return to the heart, lowering the end-diastolic volume and pressure. With less filling, the ventricle contracts with less wall tension, reducing oxygen consumption by the myocardium. While higher doses can cause some arterial dilation and a modest drop in afterload, the primary and most consistent effect at usual doses is preload reduction. Blood viscosity isn’t affected, and heart rate isn’t the main mechanism by which nitrates decrease oxygen demand.

Nitroglycerin reduces myocardial oxygen demand mainly by venodilation, which lowers preload. By dilating veins, it decreases venous return to the heart, lowering the end-diastolic volume and pressure. With less filling, the ventricle contracts with less wall tension, reducing oxygen consumption by the myocardium. While higher doses can cause some arterial dilation and a modest drop in afterload, the primary and most consistent effect at usual doses is preload reduction. Blood viscosity isn’t affected, and heart rate isn’t the main mechanism by which nitrates decrease oxygen demand.

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