In COPD, excessive oxygen delivery can lead to what adverse effect?

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Multiple Choice

In COPD, excessive oxygen delivery can lead to what adverse effect?

Explanation:
Excessive oxygen delivery in COPD can blunt the drive to breathe. In many COPD patients who chronically retain CO2, the central chemoreceptors become less responsive to CO2, so ventilation is driven more by low oxygen levels via peripheral chemoreceptors. When high concentrations of oxygen are given, the rise in arterial O2 reduces this peripheral stimulus, causing hypoventilation and a rise in CO2 (hypercapnia). This can worsen respiratory status, so oxygen is given with careful titration to keep saturations in a safe target range (around 88–92%). Other potential effects listed—hypoglycemia, dehydration, or increased renal function—aren’t caused by oxygen delivery in COPD.

Excessive oxygen delivery in COPD can blunt the drive to breathe. In many COPD patients who chronically retain CO2, the central chemoreceptors become less responsive to CO2, so ventilation is driven more by low oxygen levels via peripheral chemoreceptors. When high concentrations of oxygen are given, the rise in arterial O2 reduces this peripheral stimulus, causing hypoventilation and a rise in CO2 (hypercapnia). This can worsen respiratory status, so oxygen is given with careful titration to keep saturations in a safe target range (around 88–92%). Other potential effects listed—hypoglycemia, dehydration, or increased renal function—aren’t caused by oxygen delivery in COPD.

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